• One possible explanation for differences in the

  2019-12-16

  

  One possible explanation for differences in the binding ability of monomeric versus dimeric forms of DDR2 ECD to collagen could be that the monomeric form only binds to the primary GVMGFO site, whereas dimeric (and oligomeric) DDR2 ECD binds to additional sites on the collagen triple-helical molecul

• br Role of cysLT signaling on

  2019-12-16

  

  Role of cysLT signaling on various neurological complications which are associated with Alzheimer’s disease Alzheimer’s disease, first described in 1906 by Alois Alzheimer, is a neurodegenerative disease and a very common cause of dementia progressively leading to death. Even though years of rese

• br Results br Discussion SDF performs essential

  2019-12-16

  

  Results Discussion SDF-1 performs essential roles in cell migration and proliferation, acts as neuromodulator; and is also involved in many pathological processes including human immunodeficiency virus infection, metastatic malignancy, and chronic inflammatory disorders (Feng et al., 1996, Li

• Unexpectedly CRF receptor agonist and antagonist

  2019-12-16

  

  Unexpectedly, CRF2 receptor agonist and antagonist evoked similar effects in the fall in tail skin temperature caused by restraint. However, Ucn3 reduced basal values of tail skin temperature, thus indicating that some degree of basal vasoconstriction caused by BNST treatment with Ucn3 may have cont

• br Acknowledgements This study was financially supported by

  2019-12-16

  

  Acknowledgements This study was financially supported by the National Special Research Programs for Non-Profit Trades (Agriculture) (Grant No. 201303045) and the Basic Foundation for Scientific Research of the State-level Public Welfare Institutes of China (Grant No. 2013JB10). Introduction L

• The endothelin receptor type B EDNRB

  2019-12-16

  

  The endothelin receptor type B (EDNRB) belongs to the family of G protein-coupled receptors, which functions as a vital regulatory factor in signal transduction in cells, locating on human chromosome 13q22.3 (Ayala-Valdovinos et al., 2016; Bregar et al., 2018; Morimoto et al., 2018; Widowati et al.,

• Widely expressed mammalian adhesion receptors for fibrillar

  2019-12-16

  

  Widely expressed mammalian adhesion receptors for fibrillar collagens include the α2β1- and α11β1-integrins and the discoidin domain receptors (DDRs), DDR1 and DDR2 (Leitinger, 2011). Integrins and DDRs bind distinct and separate motifs in native fibrillar collagen (Curat et al., 2001, Vogel et al.,

• br Introduction Alzheimer s disease AD is

  2019-12-16

  

  Introduction Alzheimer’s disease (AD) is the progressive version of mild cognitive impairment and usually met by the elderly population. It falls into the class of neurodegenerative disorders that attacks the Splitomicin mg nerves cells, or neurons, resulting in loss of memory, impairment of thi

• Introduction Angiotensin II Ang II and Endothelin ET are pot

  2019-12-14

  

  Introduction Angiotensin II (Ang II) and Endothelin 1 (ET-1) are potent vasoconstrictive peptides recognized as key players in many cardiovascular diseases [1]. Cardiac hypertrophy, ischemic arrhythmia, and stroke have been associated to an overstimulation of the angiotensin II type 1 (AT1) recepto

• br The modulation of ER

  2019-12-14

  

  The modulation of ERα: from SERMs to TSECs Continued efforts to provide women with efficacious menopausal therapies have generated interest in the development of selective loxo 101 sale receptor modulators (SERMs). Similar to estrogens, SERMs have been shown to bind to ERs with high affinity, de

• The present study also showed that EP

  2019-12-14

  

  The present study also showed that EP2 deficiency and EP4 antagonism significantly suppressed psoriatic thip receptor in an imiquimod model. Notably, however, the combined EP2 deficiency and EP4 antagonism did not completely suppress ear swelling in this model, possibly because there is the IL-17–i

• BQ-123 synthesis Covalent inhibitors are well suited for tar

  2019-12-14

  

  Covalent inhibitors are well suited for targeting the E1 BQ-123 synthesis of Ubl modifications. Because the E1 enzymes in Ubl modifications, such as the SUMO E1 and Atg7, have a slow turnover rate (Boggio et al., 2004), prolonged inhibition can be achieved without requiring compounds to be stable i

• 2-Palmitoylglycerol The most significant finding was the inh

  2019-12-14

  

  The most significant finding was the inhibition of EROD and BFCOD activity by CLO. Inhibition of EROD and BFCOD were reversible, as pre-incubation did not enhance CLO inhibitory potency, and no reductions in IC50 values were observed. We further characterized the kinetic pattern of inhibition using

• Our study found a significant

  2019-12-14

  

  Our study found a significant association between the degree of primary tumor lobulation and EGFR mutations status (P NECA status. However, only a small portion of these previous studies included the evaluation of lobulation, and almost all of them reported no association between EGFR mutations and

• We initially identified four putative Egr binding sites

  2019-12-14

  

  We initially identified four putative Egr1 2665 (−39/−36, −105/−102, −107/−104, and −227/−224) on the DBH proximal promoter. The deletion and mutagenesis experiments indicate that the motif at −227/−224 is required for Egr1-elicited reduction in DBH promoter activity. It remains to be determined whe

11402 records 604/761 page Previous Next First page 上5页 601602603604605 下5页 Last page